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Protecting DNA is vital to thwarting age-related conditions. Guardian proteins called sirtuins do this by modulating DNA repair. They also participate in critical metabolic processes like immune responses.
NAD+ is a life-preserving coenzyme. Without NAD+, metabolic homeostasis collapses, and cells become vulnerable to stress-related damage. Thus, identifying new modalities to sustain NAD+ levels is critical for healthy aging.
Senescent cells accumulate with age and promote tissue deterioration. They are implicated in many harmful age-related health conditions. Senolytics have the unique ability to selectively target and eliminate senescent cells.